physician photo

Brian W. Wong, PhD

  • Assistant Professor of Surgery

Graduate School

PhD (2011), Cardiovascular Research Laboratory, Centre for Heart Lung Innovation, St. Paul’s Hospital, Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada [mentor: Bruce M. McManus, MD, PhD, FRSC, FCAHS, FRCPC, FCAP, FACC]

Post Doctoral Education

Postdoctoral fellowship (2011-2017), Laboratory of Angiogenesis & Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium [mentor: Peter Carmeliet, MD, PhD]

Research Interests

role of lymphatic vessels in solid organ allograft rejection
metabolic and epigenetic regulatory pathways that regulate lymphatic biology and inflammation
developing novel therapeutics to improve graft outcome and prevent solid organ rejection

Selected Publications

Wong BW, Marsch E, Treps L, Baes M, Carmeliet P. Endothelial cell metabolism in health and disease: Impact of hypoxia. EMBO J. EMBO J. 2017; 36:2187-2203.

Wong BW*, Wang X*, Zecchin A*, Thienpont B, Cornelissen I, Kalucka J, García-Caballero M, Missiaen R, Huang H, Brüning U, Blacher S, Vinckier S, Goveia J, Knobloch M, Zhao H, Dierkes C, Shi C, Hägerling R, Moral-Dardé V, Wyns S, Lippens M, Jessberger S, Fendt SM, Luttun A, Noel A, Kiefer F, Ghesquière B, Moons L, Schoonjans L, Dewerchin M, Eelen G, Lambrechts D, Carmeliet P. Role of fatty acid ß-oxidation in lymphangiogenesis. Nature. 2017; 542:49-54.

Chatur S, Wong BW, Carthy JM, McManus BM. Inhibition of vascular endothelial growth factor reduces cardiac allograft vasculopathy. J Heart Lung Transplant. 2016; 35:1124-30. [Impact factor – 7.114]

Cruys B, Wong BW, Kuchnio A, Verdegem D, Vinckier S, Merks RM, Dewerchin M, Gerhardt H, Bentley K, Carmeliet P. Glycolytic regulation of cell rearrangement in angiogenesis. Nat Commun. 2016; 7:12240.

de Zeeuw P, Wong BW, Carmeliet P. Metabolic adaptations in diabetic endothelial cells. Circ J. 2015; 79: 934-41.

Ghesquière B, Wong BW, Kuchnio A, Carmeliet P. Metabolism of stromal and immune cells in health and diseases. Nature. 2014; 511: 167-76.

De Bock K*, Georgiadou M*, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell. 2013; 154: 651-663.

Wong BW, Kuchnio A, Bruning U, Carmeliet P. Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes. Trends Biochem Sci. 2013; 38: 3-11.

Wong BW, Meredith A, Lin D, McManus BM. The biological role of inflammation in atherosclerosis. Can J Cardiol. 2012; 28: 631-41.

Wong BW, Wong D, Luo H, McManus BM. Vascular endothelial growth factor-D is overexpressed in human cardiac allograft vasculopathy and diabetic atherosclerosis and induces endothelial permeability to low-density lipoproteins in vitro. J Heart Lung Transplant. 2011; 30: 955-62.

Wong BW, Rahmani M, Luo Z, Yanagawa B, Wong D, Luo H, McManus BM. Vascular endothelial growth factor increases human cardiac microvascular endothelial cell permeability to low-density lipoproteins. J Heart Lung Transplant. 2009; 28: 950-7.

Luo H, Wong J, Wong B. Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy. Cardiovasc Res. 2010; 85: 347-56. Review.

Wong BW, Rahmani M, Rezai N, McManus BM. Progress in heart transplantation. Cardiovasc Pathol. 2005; 14: 176-80.

Wong BW, Wong D, McManus BM. Characterization of fractalkine (CX3CL1) and CX3CR1 in human coronary arteries with native atherosclerosis, diabetes mellitus, and transplant vascular disease. Cardiovasc Pathol. 2002; 11: 332-8.

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