physician photo

William C. Chapman, MD, FACS

  • Eugene M. Bricker Chair of Surgery
  • Chief, Division of General Surgery
  • Chief, Section of Transplantation and Surgical Director, Transplant Center

Medical School

Medical School: Medical University of South Carolina, Charleston, SC, 1984

Post Doctoral Education

Fellowship:  Pathogenesis of Liver and Biliary Tract Disease, Vanderbilt University, 1989

Residency: General Surgery, Vanderbilt University Hospital, Nashville, TN, 1991

Fellowship: Hepatobiliary Surgery and Liver Transplantation, Kings College Hospital, London, England, 1992

Board Certifications

American Board of Surgery
American Board of Surgery, Added Qualifications in Surgical Critical Care
Fellow American College of Surgeons

Honors and Awards

President, American Hepato-Pancreato-Biliary Association (AHPBA), 2012-13

Chair, Business Practice Committee, American Society of Transplant Surgeons (ASTS)

Listed in Best Doctors in America, (Best Doctors, Inc.), 2017

John L. Sawyers Award for Resident Education, Vanderbilt University Medical Center, 2001

J. Bradley Aust Award, Western Surgical Association, 1999

Harwell Wilson Chief Resident Award, Vanderbilt University Medical Center, 1991

Clinical Interests

Liver transplantation
Liver surgery
Bile duct surgery
Liver tumor treatment
Radiofrequency ablation
Image-guided liver surgery

Research Interests

Hepatocellular carcinoma (HCC)

Development of image-guided liver surgery. This project facilitates the use of tomographic imaging to provide guidance during hepatic resection and ablation procedures.

Investigation of mechanisms of liver-mediated multi-system injury. This project investigates NF-kappa B-mediated multisystem injury following direct hepatic ischemia reperfusion injury.


NIH (PO1 HL66196-01) Multisystem injury following Direct Liver Injury
NIH (1R21 CA/R 91352-01) Image-Guided Liver Surgery

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children’s Hospital
St. Louis Veteran's Administration Medical Center

Patients Seen At

Center for Advanced Medicine
GI Center
4921 Parkview Place, 8th Floor, Suite C
St. Louis, MO 63110
(314) 362-2538 (for patients)
Fax: (314) 361-4197

Contact Information

Washington University School of Medicine
Department of Surgery
Section of Transplantation Surgery
Campus Box 8109, 660 S. Euclid Ave.
St. Louis, MO 63110
(314) 362-7792

Selected Publications

Khan A, Fowler K, Chapman WC. Current surgical treatment strategies for hepatocellular carcinoma in North America. World Journal of Gastroenterology. 2014;20(41):15007-15017.

Lin Y*, Manning P*, Jia J, Gaut J, Xiao Z, Capoccia B, Chen C, Ronald H, Upadhya G, Mohanakumar T, Frazier W, Chapman WC. CD 47 Blockade Reduces Ischemia-Reperfusion Injury and Improves Outcomes in a Rat Kidney Transplant Model. Transplantation (online first), 2014.

Vannucci A, Rathor R, Vachharajani N, Chapman WC, Kangrga I. Atrial Fibrillation in Patient Undergoing Liver Transplantation: A Single-Center Experience. Transplantation Proceedings. 2014;46:1432-1437,

Hagan M, Sayuk G, Lisker-Melman M, Korenblat K, Kerr T, Chapman WC, Crippin J. Liver Voume in the Cirrhotic Patient: Does Size Matter? Dig Dis Sci. 2014;59:886-891,

Jin L, Pitt S, Doyle M, Klein C, Shenoy S, Lowell J, Chapman WC, Wellen J. Effect of Donor Body Mass Index on the Outcome of Donation After Cardiac Death Kidneys: How Big is Too Big? Transplantation Proceedings. 2014;46: 46-49.

Sarma N, Tiriveedhi V, Crippin J, Chapman WC, Mohanakumar T. Hepatitis C Virus-Induced Changes in MicroRNA 107 (miRNA-107) and miRNA-449a Modulate CCL2 by Targeting the interleukin-6 Receptor Complex in Hepatitis. J Virol. 2014;88(7):3733.

Blinder M, Geng B, Lisker-Melman M, Crippin J, Korenblat K, Chapman WC, Shenoy S, Field J. Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature. Hematology Reports. 2013;5(1).

Fowler K, Karimova E, Arauz A, Saad N, Brunt E, Chapman WC, Heiken J. Validation of Organ Procurement and Transplant Network (OPTN)/United Network for Organ Sharing (UNOS) Criteria for Imaging Diagnosis of Hepatocellular Carcinoma. Transplantation. 2013;95(12).

Subramanian V, Bharat A, Vachharajani N, Crippin J, Shenoy S, Mohanakumar T, Chapman WC. Perioperative blood transfusion affects hepatitis C virus (HCV)-specific immune responses and outcome following liver transplantation in HCV-infected patients. HPB; DOI:1o.1111/hpb.12128, 2013.

Ramachanran S, Basha H, Sarma N, Lin Y, Crippin J, Chapman WC, Mohanakumar T. Hepatitis C Virus Induced miR200c Down Modulates FAP-1, a Negative Regulator of Src Signaling and Promotes Hepatic Fibrosis. PLoS ONE 2013;8(8): e70744. doi:10.1371/journal.pone.0070744.

Liu T, Vachharajani N, Chapman WC, Brunt E. Noncirrhotic hepatocellular carcinoma: derivation from hepatocellular adenoma? Clinicopathologic analysis. Modern Pathology; 2013;1-13.

Angaswamy N, Tiriveedhi V, Sarma N, Subramanian V, Klein C, Wellen J, Shenoy S, Chapman WC, Mohanakumar T. Interplay between immune responses to HLA and non-HLA self-antigens in allograft rejection. Human Immunology. 2013;74:1478-1485..

Fowler KJ, Sheybani A, Parker, RA, Doherty S, Brunt EM, Chapman WC. Combined hepatocellular and cholangiocarcinoma (biphenotypic) tumors: Imaging features and diagnostic accuracy of contrast-enhanced CT and MRI. American Journal of Roentgenology. 2013;201(2): 332-339.

Ralene T, Bowman, L, Crippin J, Chapman WC, Anderson CD. Once Weekly Fluconazole for Antifungal Prophylaxis Post-liver Transplantation. HPB. 2013;15(7): 541-547.

Ma C, Crippin JS, Chapman WC, Korenblat K, Vachharajani N, Gunter KL, Brunt EM. Parenchymal alterations in cirrhotic livers in patients with hepatopulmonary syndrome or portopulmonary hypertension. Liver Transpl. 2012;19(7):741-50.      

Pub Med page for William C. Chapman, M.D.