physician photo

William C. Chapman, MD, FACS

  • Eugene M. Bricker Chair of Surgery
  • Chief, Division of General Surgery
  • Chief, Section of Transplantation and Surgical Director, Transplant Center

Medical School

Medical School: Medical University of South Carolina, Charleston, SC, 1984

Post Doctoral Education

Fellowship:  Pathogenesis of Liver and Biliary Tract Disease, Vanderbilt University, 1989

Residency: General Surgery, Vanderbilt University Hospital, Nashville, TN, 1991

Fellowship: Hepatobiliary Surgery and Liver Transplantation, Kings College Hospital, London, England, 1992

Board Certifications

American Board of Surgery
American Board of Surgery, Added Qualifications in Surgical Critical Care
Fellow American College of Surgeons

Honors and Awards

President, American Hepato-Pancreato-Biliary Association (AHPBA), 2012-13

Chair, Business Practice Committee, American Society of Transplant Surgeons (ASTS)

Listed in Best Doctors in America, (Best Doctors, Inc.), 2012

Listed in America's Top Doctors, Castle Connolly Medical Ltd., 2010

John L. Sawyers Award for Resident Education, Vanderbilt University Medical Center, 2001

J. Bradley Aust Award, Western Surgical Association, 1999

Harwell Wilson Chief Resident Award, Vanderbilt University Medical Center, 1991

Clinical Interests

Liver transplantation
Liver surgery
Bile duct surgery
Liver tumor treatment
Radiofrequency ablation
Image-guided liver surgery

Research Interests

Hepatocellular carcinoma (HCC)

Development of image-guided liver surgery. This project facilitates the use of tomographic imaging to provide guidance during hepatic resection and ablation procedures.

Investigation of mechanisms of liver-mediated multi-system injury. This project investigates NF-kappa B-mediated multisystem injury following direct hepatic ischemia reperfusion injury.


NIH (PO1 HL66196-01) Multisystem injury following Direct Liver Injury
NIH (1R21 CA/R 91352-01) Image-Guided Liver Surgery

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children’s Hospital
St. Louis Veteran's Administration Medical Center

Patients Seen At

Center for Advanced Medicine
GI Center
4921 Parkview Place, 8th Floor, Suite C
St. Louis, MO 63110
(314) 362-2538 (for patients)
Fax: (314) 361-4197

Contact Information

Washington University School of Medicine
Department of Surgery
Section of Transplantation Surgery
Campus Box 8109, 660 S. Euclid Ave.
St. Louis, MO 63110
(314) 362-7792

Selected Publications

DuBray BJ Jr, Levy RV, Balachandran P, Conzen KD, Upadhya GA, Anderson CD, Chapman WC. Novel three-dimensional imaging technique improves the accuracy of hepatic volumetric assessment. HPB (Oxford). 2011 Sep;13(9):670-4.

DuBray BJ Jr, Chapman WC, Anderson CD. Hepatocellular carcinoma: a review of the surgical approaches to management. Mo Med. 2011 May-Jun;108(3):195-8.

Lennerz JK, Chapman WC, Brunt EM. Keratin 19 epithelial patterns in cirrhotic stroma parallel hepatocarcinogenesis. Am J Pathol. 2011 Aug;179(2):1015-29.

Earl TM, Chapman WC. Conventional Surgical Treatment of Hepatocellular Carcinoma. Clin Liver Dis. 2011 May;15(2):353-70, vii-x. Review.

Lin Y, Chapman WC. Towards more effective liver allocation criteria for hepatocellular carcinoma: tumor response to locoregional therapy. Ann Surg Oncol. 2011 Sep;18(9):2416-8.

Earl TM, Chapman WC. Tumor size remains key for prediction of hepatocellular carcinoma recurrence after liver transplantation. Ann Surg Oncol. 2011 May;18(5):1217-8.

Anderson CD, Upadhya G, Conzen KD, Jia J, Brunt EM, Tiriveedhi V, Xie Y, Ramachandran S, Mohanakumar T, Davidson NO, Chapman WC. Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts. Liver Transpl. 2011 Feb;17(2):189-200.

Doyle MB, Vachharajani N, Wellen JR, Anderson CD, Lowell JA, Shenoy S, Brunt EM, Chapman WC. Short- and long-term outcomes after steatotic liver transplantation. Arch Surg. 2010 Jul;145(7):653-60.

Bowman LJ, Anderson CD, Chapman WC. Topical recombinant human thrombin in surgical hemostasis. Semin Thromb Hemost. 2010 Jul;36(5):477-84.

Jarnagin W, Chapman WC, Curley S, D'Angelica M, Rosen C, Dixon E, Nagorney D. Surgical treatment of hepatocellular carcinoma: expert consensus statement. HPB (Oxford). 2010 Jun;12(5):302-10.

Doyle MB, Chapman WC. Radiofrequency ablation for resectable colorectal hepatic metastases: is it time for a randomized controlled trial? Ann Surg. 2010 May;251(5):804-6

Ballard JL, Weaver FA, Singla NK, Chapman WC, Alexander WA. Safety and immunogenicity observations pooled from eight clinical trials of recombinant human thrombin. J Am Coll Surg. 2010 Feb;210(2):199-204

Anderson CD, Turmelle YP, Darcy M, Shepherd RW, Weymann A, Nadler M, Guelker S, Chapman WC, Lowell JA. Biliary strictures in pediatric liver transplant recipients - early diagnosis and treatment results in excellent graft outcomes. Pediatr Transplant. 2010 May;14(3):358-63

Wellen JR, Anderson CD, Doyle M, Shenoy S, Nadler M, Turmelle Y, Shepherd R, Chapman WC, Lowell JA. The role of liver transplantation for hepatic adenomatosis in the pediatric population: case report and review of the literature. Pediatr Transplant. 2010 May;14(3):E16-9

Bender LC, Klingensmith ME, Freeman BD, Chapman WC, Dunagan WC, Gottlieb JE, Hall BL. Anonymous group peer review in surgery morbidity and mortality conference. Am J Surg. 2009 Aug;198(2):270-6

Pub Med page for William C. Chapman, M.D.