physician photo

Yiing Lin, MD, PhD

  • Assistant Professor of Surgery

Medical School

MD, Washington University School of Medicine, St. Louis, MO, 1997-2005

Graduate School

PhD, Genetics, Washington University School of Medicine, St. Louis, MO 1997-2005

Post Doctoral Education

Intern, Surgery, Barnes-Jewish Hospital/Washington University School of Medicine, St. Louis, MO, 2005-2006

Resident, Surgery Barnes-Jewish Hospital/Washington University School of Medicine, St. Louis, MO, 2006-2010

Fellow, Transplantation, Washington University School of Medicine, St. Louis, MO, 2010 - 2012

Board Certifications

Board certified by the American Board of Surgery

Clinical Interests

Kidney transplantation
Liver transplantation

Research Interests

Use of computational methods to investigate the genetics of gastrointestinal malignancies. Tumor genetics of hepatocellular carcinoma. Hereditary colorectal cancer.

Hospital Affiliations

Barnes-Jewish Hospital

Patients Seen At

Center for Advanced Medicine
4921 Parkview Place, Suite C , 8th Floor
St. Louis, MO 63110
(314) 747-1393

Selected Publications

Lin S*, Lin Y*, Nery JR, Urich MA, Breschi A, Davis CA, Dobin A, Zaleski C, Beer MA, Chapman WC, Gingeras TR, Ecker JR, Snyder M. Comparison of the transcriptional landscapes between human and mouse tissues. Proc. Natl. Acad. Sci. U. S. A. 2002. doi:10.1073/pnas.1413624111

Lin Y, Manning PT, Jia J, Gaut JP, Xiao Z, Capoccia BJ, Chen C-C, Hiebsch RR, Upadhya G, Mohanakumar T, Frazier W a, Chapman WC. CD47 blockade reduces ischemia-reperfusion injury and improves outcomes in a rat kidney transplant model. Transplantation 2014;98(4):394-401. doi:10.1097/TP.0000000000000252

Cheng Y, Ma Z, Kim B-H, Wu W, Cayting P, Boyle AP, Sundaram V, Xing X, Dogan N, Li J, Euskirchen G, Lin S, Lin Y, Visel A, Kawli T, Yang X, Patacsil D, Keller C a., Giardine B, Kundaje A, Wang T, Pennacchio L a., Weng Z, Hardison RC, Snyder MP. Principles of regulatory information conservation between mouse and human. Nature 2014;515(7527):371-375. doi:10.1038/nature13985

Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD, Shen Y, Pervouchine DD, Djebali S, Thurman RE, Kaul R, Rynes E, Kirilusha A, Marinov GK, Williams B a., Trout D, Amrhein H, Fisher-Aylor K, Antoshechkin I, DeSalvo G, See L-H, Fastuca M, Drenkow J, Zaleski C, Dobin A, Prieto P, Lagarde J, Bussotti G, Tanzer A, Denas O, Li K, Bender M a., Zhang M, Byron R, Groudine MT, McCleary D, Pham L, Ye Z, Kuan S, Edsall L, Wu Y-C, Rasmussen MD, Bansal MS, Kellis M, Keller C a., Morrissey CS, Mishra T, Jain D, Dogan N, Harris RS, Cayting P, Kawli T, Boyle AP, Euskirchen G, Kundaje A, Lin S, Lin Y, Jansen C, Malladi VS, Cline MS, Erickson DT, Kirkup VM, Learned K, Sloan C a., Rosenbloom KR, Lacerda de Sousa B, Beal K, Pignatelli M, Flicek P, Lian J, Kahveci T, Lee D, James Kent W, Ramalho Santos M, Herrero J, Notredame C, Johnson A, Vong S, Lee K, Bates D, Neri F, Diegel M, Canfield T, Sabo PJ, Wilken MS, Reh T a., Giste E, Shafer A, Kutyavin T, Haugen E, Dunn D, Reynolds AP, Neph S, Humbert R, Scott Hansen R, De Bruijn M, Selleri L, Rudensky A, Josefowicz S, Samstein R, Eichler EE, Orkin SH, Levasseur D, Papayannopoulou T, Chang K-H, Skoultchi A, Gosh S, Disteche C, Treuting P, Wang Y, Weiss MJ, Blobel G a., Cao X, Zhong S, Wang T, Good PJ, Lowdon RF, Adams LB, Zhou X-Q, Pazin MJ, Feingold E a., Wold B, Taylor J, Mortazavi A, Weissman SM, Stamatoyannopoulos J a., Snyder MP, Guigo R, Gingeras TR, Gilbert DM, Hardison RC, Beer M a., Ren B. A comparative encyclopedia of DNA elements in the mouse genome. Nature 2014;515(7527):355-364. doi:10.1038/nature13992

Blanc V, Park E, Schaefer S, Miller M, Lin Y, Kennedy S, Billing AM, Ben Hamidane H, Graumann J, Mortazavi A, Nadeau JH, Davidson NO. Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver. Genome Biol. 2014;15(6):R79. doi:10.1186/gb-2014-15-6-r79

Conzen KD, Vachharajani N, Collins KM, Anderson CD, Lin Y, Wellen JR, Shenoy S, Lowell JA, Doyle MBM, Chapman WC. Morbid obesity in liver transplant recipients adversely affects longterm graft and patient survival in a single-institution analysis. HPB (Oxford). 2014. doi:10.1111/hpb.12340

Cavaness KM, Doyle MBM, Lin Y, Maynard E, Chapman WC. Using ALPPS to induce rapid liver hypertrophy in a patient with hepatic fibrosis and portal vein thrombosis. J. Gastrointest. Surg. 2013;17(1):207-12. doi:10.1007/s11605-012-2029-9

Doyle MBM, Maynard E, Lin Y, Vachharajani N, Shenoy S, Anderson C, Earl M, Lowell J, Chapman WC. Outcomes with split liver transplantation are equivalent to those with whole organ transplantation. J. Am. Coll. Surg. 2013;217(1):102-12; discussion 113-4. doi:10.1016/j.jamcollsurg.2013.03.003

Ramachandran S, Ilias Basha H, Sarma NJ, Lin Y, Crippin JS, Chapman WC, Mohanakumar T. Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis. PLoS One 2013;8(8):e70744. doi:10.1371/journal.pone.0070744

Lin Y, Lin S, Watson M, Trinkaus KM, Kuo S, Naughton MJ, Weilbaecher K, Fleming TP, Aft RL. A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy. Breast Cancer Res. Treat. 2010;123(3):691-9. doi:10.1007/s10549-009-0664-y

Lin Y, Goedegebuure PS, Tan MCB, Gross J, Malone JP, Feng S, Larson J, Phommaly C, Trinkaus K, Townsend RR, Linehan DC. Proteins associated with disease and clinical course in pancreas cancer: a proteomic analysis of plasma in surgical patients. J. Proteome Res. 2006;5(9):2169-76. doi:10.1021/pr0600374

Lin Y, Stormo GD, Taghert PH. The neuropeptide pigment-dispersing factor coordinates pacemaker interactions in the Drosophila circadian system. J. Neurosci. 2004;24(36):7951-7. doi:10.1523/JNEUROSCI.2370-04.2004

Lin Y, Han M, Shimada B, Wang L, Gibler TM, Amarakone A, Awad T a, Stormo GD, Van Gelder RN, Taghert PH. Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster. Proc. Natl. Acad. Sci. U. S. A. 2002;99(14):9562-7. doi:10.1073/pnas.132269699 PMCID: PCM123180

 

Chapters

Taghert PH, Lin Y. Tick-talk: the cellular and molecular biology of Drosophila circadian rhythms. In: Gilbert LI, Iatrou K, Gill SS (editors). Comprehensive Molecular Insect Science Amsterdam. Elsevier; 2005:357-395.

Lin Y, Chapman WC. Towards more effective liver allocation criteria for hepatocellular carcinoma: tumor response to locoregional therapy. Annals of Surgical Oncology. 2011 Epub ahead of print.